As if the divisions within the cabinet over Brexit weren't trouble enough for the Prime Minister, a vote in the Scottish parliament today has paved the way for a potential constitutional crisis.
Challenged by SNP Westminster leader Ian Blackford at Prime Minister's Questions, Mrs May said the Withdrawal Bill "respects devolution and lets us maintain the integrity of our own common market".
"This is a historic and significant moment for the Scottish Parliament and I hope with all sincerity that the United Kingdom government will respect the views of this parliament", Bruce Crawford, who heads the assembly's Finance and Constitution Committee, said after the vote.
Though Tuesday's vote is not binding, it does put Theresa May into uncharted territory.
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The Scottish government has urged the Parliament in Edinburgh to refuse "legislative consent" for the highly contested EU (Withdrawal) Bill now being debated by lawmakers in London.
"I think this is a reasonable, a sensible way forward - the Welsh government, and now the Welsh Assembly including Labour and Liberal Democrat members of the Welsh Assembly, agree with that".
Speaking on TalkRadio, Mr Jenkin said: "There's something of a manufactured row here that, of course, the powers that we are talking about were held by the European Union and were never held by the Scottish Parliament".
The dispute centres on who will have control of powers now residing in Brussels, such as over farming and fisheries, once Britain leaves the EU.
The British government said it would refer the bill to legal officers and a hearing is scheduled for July in the Supreme Court unless agreement can be found before then. "It becomes a bigger issue at the point when the bill is completing its passage through Westminster".
An initial proposal past year by Britain that devolved powers returning from the European Union after Brexit should initially pass to Westminster was roundly rejected by Welsh and Scottish politicians. The U.K. can disregard the vote, but it would be the first time London asserts its dominance over the regional parliament. Now she's at risk of having to impose British sovereignty against the will of the Scottish Parliament unless there's a compromise on what the Scots are calling a "power grab".