In a news conference on May 29, he said: "The last few months have been incredibly hard, for me, for my family, for my team, for my friends and for many, many people that I love".
A year after Greitens took office in January 2017, he became engulfed in scandal when he admitted to a 2015 extramarital affair but denied allegations he threatened his lover with a compromising photograph.
Prior to taking office, Greitens had pledged to root out "corrupt career politicians", but his brief, 17-month tenure was plagued by scandal. Greitens is accused of using a donor's list from the Mission Continues Charity that he founded to help raise money during his campaign.
Less than two weeks ago, the legislature began meeting in special sessions to consider impeachment proceedings against him.
A special investigative committee in the house has already released two ruinous reports against Greitens. There was concern that the Greitens drama could pollute the state GOP, once again providing McCaskill with a possible lifeboat created by Republicans. Greitens' legal bills had grown to a couple of million dollars, and his campaign staffers also were facing legal bills because of subpoenas from a House investigation.
"Millions of dollars of mounting legal bills, endless personal attacks created to cause maximum damage to family and friends, legal harassment of colleagues, friends and campaign workers, and it's clear that for the forces that oppose us, there's no end in sight".
Responding to Grietens' past statements calling the prosecution "a witch hunt" that inflicted pain on his family, Gardener said the governor had brought the charges upon himself "by his actions, his statements, his decisions, his ambition and his pursuit for power".
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Missouri Attorney General Josh Hawley, who called for Greitens to resign on multiple occasions, said he did the right thing on Tuesday.
Political science professor Jeremy Walling, of Southeast Missouri State University, said Greitens' pledge to keep fighting seemed to be "some face-saving".
Circuit Attorney Kimberly Gardner will dismiss a felony computer-tampering charge against Missouri Gov. Eric Greitens as part of an agreement reached with his attorneys, Gardner announced Wednesday. One of the open stipulations states that Greitens has agreed to release Gardner and everyone in her office from civil liability. The dropped charge was the result of a deal proposed Saturday by Greitens' defense attorneys offering his resignation in exchange, said Gardner spokeswoman Susan Ryan.
"This is not the end of our fight", Greitens said.
It also happened on the same day a judge ordered Greitens to turn over information related to campaign payments he received from a group named A New Missouri. "I don't believe the market was treating the state's constitutional crisis surrounding the impeachment process as any sort of a credit risk".
Greitens said his resignation would take effect Friday. Some considered him a potential future presidential contender.
Earlier this month, Gardner's office dropped the invasion of privacy case against Greitens.