Uruguay head coach Oscar Tabarez.
The Atletico Madrid pair of Diego Godin and Jose Maria Gimenez will be charged with keeping Ronaldo quiet, and Portugal coach Fernando Santos warned his side not to expect their captain to win the tie on his own for the European champions.
"We will take him seriously, but we will not be obsessed by it".
Yet the Barcelona striker bounced back by hitting the victor to down Saudi Arabia before finding the net again in a 3-0 win over Russian Federation, as Uruguay headed into the knockout rounds with maximum points. "You don't prepare a match just looking at one player".
Tabarez, who is in his 14th year as Uruguay manager, albeit across two spells, is understandably planning that his side will have to work as a team to contain the five-time Ballon D'Or victor.
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Kun is Argentina's only goalscorer so far, netting a superb opener in the 1-1 draw against Iceland. And he will hope his showing against the Vikings help him tie down a starting spot on Tuesday.
Uruguay are yet to concede at the World Cup, but Portugal have kept only one clean sheet.
"It's the team that has to play, if Ronaldo plays alone we're going to lose". - All five of Uruguay's goals at Russian Federation 2018 have been scored from set pieces (three from corners, 1 from direct free kick and 1 from an indirect free kick). "He has a great potential obviously and in planning the match, especially focusing on the opponent and considering the level that every player has. what Ronaldo has on top of the qualities is that he's the leader of that team".
"We'll be focused. But nine of those Portuguese players on that pitch are European Champions".
- Luis Suarez has scored seven World Cup goals for Uruguay, second only to Oscar Miguez (eight) - Suarez scored a brace against South Korea in his only previous appearance in the round of 16 back in 2010.
"I don't think it will be a duel between Suarez and Ronaldo", Alves said on Thursday. I've told them they need to be calm.
"We have known each other for a long time and have played together for over 10 years in the national team", Suarez said of Cavani. Excelling in their man-management skills, they surely have the strategic know-how and they have already led their sides to continental glory; and simply an iota of sparked brilliance could decide the game today. We've shown we have the chance to win and if we keep it up this way I think we'll be successful.