Sanctions will apply to other countries if they help Iran develop nuclear weapons, warned the United States.
Iran has been furious over U.S. President Donald Trump's decision to pull out of an global nuclear deal and reimpose sanctions on Tehran.
Officials have urged Iranian citizens to remain calm and to hold out through the rough times promised by Washington, noting that the country will weather the latest storm wrought by Trump and his apparently "regime change"-focused administration of pro-Israeli, pro-Saudi hawks".
In short, Trump withdrew from the Iran deal, likely imposed tremendous cost and stress on Tehran's economy, and Iran has responded by staying in the deal and trying to portray itself as a good actor worthy of the world's support against U.S. hegemony.
And John Bolton, the president's national security adviser, is a well-known Iran hawk who has advocated for regime change.
Iran has reacted negatively to US President Donald Trump's offer of bilateral negotiations, with the head of the Revolutionary Guards dismissing the idea outright, writes Nassir Shirkhani.
European countries, along with Russian Federation and China, remain committed to the nuclear deal, but European companies are unlikely to risk USA sanctions to do business with Iran.
Nevertheless, Iranians have been demonstrating since December 2017 against the high cost of living and the systematic corruption within the system. Representatives of the administration trump says that the sanctions resume "in an attempt to change the behavior of the Iranian regime".
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Iran's oil exports could fall by as much as two-thirds by the end of the year because of the US sanctions, putting oil markets under strain amid supply outages elsewhere in the world.
Pompeo said it would require "enormous change" by Iran to get out from under renewed USA sanctions.
In some cities like Shiraz riot police forces used tear gas to push back protesters, according to Radio Zamaneh.
The sanctions that go back into effect on Monday cover Iranian trade in automobiles and metals, including gold.
The U.S. has been pushing its allies to halt their import of Iranian oil ahead of the November deadline. "If anybody's inciting anything, look no further than to Iran", press secretary Sarah Sanders said and added that President Trump has been "very clear about what he's not going to allow to take place".
The report said a protest was taking place in Karaj, 50 kilometers (30 miles) west of Tehran, when someone fired from a vehicle.
He was responding to a July 22 warning from Rouhani that the USA should not "play with the lion's tail" and warned that any conflict with Iran would be the "mother of all wars".