However, Spurs have now confirmed the England global will not play again before the worldwide break, meaning he will also sit out Saturday's league game with Cardiff City.
The World Cup victor missed his side's Champions League opener, as they let slip a one-goal advantage in the closing stages to lose 2-1 to Inter in Milan.
"We went through a stage where we didn't win in three matches and maybe a bit of pressure starts to build".
Pochettino, who like Messi began his career at Newell's Old Boys in Argentina, said it was impossible to make a plan to stop him and told his players to relish the challenge.
Harry Kane was back among the goals after scoring twice during the victory at Huddersfield on Saturday and the England global will be a key player if Tottenham are to get a positive result tomorrow. We are not victims, though.
Airline now says one man missing after plane crash lands in ocean
The airline did not immediately offer any other details about the passenger, such as his age or nationality. It said it was in touch with embassies, passenger representatives, stakeholders and families of the crew.
"Messi sets the standard", Kane said. "It's only about enjoying it, being close, helping the players that are going to face him to stay close and, when you have the ball, trying to have possession, to play in the opposite half, to try to push Leo to play far from your goal". "50-60 goals a season, as a striker I want to try to match that and do the same". Every player must feel they can win and achieve what we want'.
"Messi has set the standard", he added.
Still, the Spurs boss is boosted by the return of goalkeeper Lloris for the Group B fixture in Europe, with the France global available for selection after returning to training. "He's still scoring goals as well and it motivates me as well to score as many and if not more than him one day".
Nearly ten years on, and four years since he took charge at White Hart Lane, Pochettino has proved to be the change that Tottenham Hotspur can believe...