Collison, Myles Turner and Domantas Sabonis added 15 points apiece, and Thaddeus Young had 10 for the Pacers, who were playing without Tyreke Evans.
Cleveland will face a hard task Thursday with a road game against Detroit and Blake Griffin, who scored 50 points in an overtime win over Philadelphia on Tuesday.
"We have to make shots", coach Tyronn Lue said.
Love is averaging 40.2 FanDuel points per game this season. Boston led by as many as 26 points in the second quarter, after a 12-point run from the Boston bench.
The Cavaliers' leading power forward Kevin Love missed the game with a sore left foot.
Cleveland cut a 15-point lead to 97-91 early in the fourth quarter before in regained control with four straight baskets.
Cleveland trailed just 97-91 after a Jordan Clarkson 3-pointer with 9:17 remaining before the Pacers countered with an eight-point flurry, with Darren Collison providing two of the four baskets.
Suspect in University of Utah shooting found dead
Early Tuesday morning, Salt Lake police learned Rowland was near the historic Trinity African Methodist Episcopal Church at 239 E. KSL-TV and the Salt Lake Tribune reported that authorities confirmed a female student was found dead in a vehicle on the campus.
Sabonis made another layup and Oladipo's 3-pointer with 3:58 left pushed the lead to 113-98.
The Pistons have built a 4-0 record behind a free-flowing offense featuring Blake Griffin and some good fortune.
The Celtics overcame the absence of Australian centre Aron Baynes (hamstring) and a 16-point halftime deficit to beat winless Oklahoma City 101-95 on the road. The Cavaliers cut Detroit's lead to six points at 61-55 on a Tristan Thompson layup, but Drummond and Co. led by as many as 16 in the quarter and held a 12-point edge at the start of the fourth.
Kyle Kuzma scored 22 points and JaVale McGee added 21 to complement James' 74th career triple-double, his first with his new team.
Nikola Vucevic led Orlando with 24 points and 11 rebounds.
Oklahoma City scored just one point in the final 4:14 of the game.
The Celtics led 63-41 at the half and kept a double digit for nearly the entirety of the final three quarters. Boston shot just 32 percent in the first half and missed all 11 of its 3-point attempts.