Snow totals are to taper to the northeast with parts of southwest IL forecast to receive up to 9 inches and the Chicago area expected to get between 1 and 4 inches.
St. Louis residents are digging out from a major snowstorm that buried the region with almost a foot of snow over the weekend.
The weather system, which started as rain from Mexico but has since turned into snow, is forecast to affect an 1,800-mile (2,900 km) swath of the United States from Colorado to the mid-Atlantic.
The Illinois State Police says that troopers along the Mississippi River across from St. Louis have responded to more than 100 traffic collisions during the winter storm that's rolling through the Midwest.
'We're anticipating still more snow through today, so we're asking motorists to stay home until the roads are cleared, ' said Missouri State Highway Patrol Sgt. Collin Stosberg, stationed in suburban Kansas City.
State police said the surplus vehicle's driver died at the scene.
Missouri isn't the only state being hit by this traveling snow storm.
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"With the moisture that was around an inch in liquid or more, that was plenty enough to stack up what we got across the area", he said. In Columbia, 15.5 inches were reported and Harrisburg had 17 inches.
A winter storm that blanketed the Midwest with snow and left seven dead hit Washington and its surrounding areas Sunday - with more than 35 million people under winter weather alerts.
By late Sunday afternoon, the Washington, D.C. metro area, northern Virginia and parts of Maryland had total snowfall accumulations ranging from five to eight inches (12-20 centimeters). The Missouri State Highway Patrol says almost 300 vehicles had slid off roads across the state and more than 175 crashes had been reported by late Saturday morning.
The Appalachians will pick up some snow and sleet in Virginia, down through North Carolina and Tennessee.
In Indiana, one person was killed in a crash on Interstate 70 in Greenfield on Saturday, according to WISH-TV.
For Kansas City Chiefs offensive guard Jeff Allen, there was a bright spot hen a Good Samaritan helped pull his vehicle out of the snow after he got stuck en route to Arrowhead Stadium for the divisional playoff game Saturday.
In Virginia, a 73-year-old Georgia man died Saturday, reports the AP, citing state police. Vehicle accidents resulting from icy, snow-covered roads were already being reported on Saturday evening.
The storm has forced the delay or cancellation of hundreds of flights with more expected Sunday.